Familial atypical mole and melanoma (FAM-M) syndrome is an inherited tendency to develop melanoma.

FAM-M syndrome is present when:

• Melanoma has been diagnosed in a family member, including grandparents, aunts, uncles, and cousins.
• Several family members have large numbers of moles (often more than 50), some of which may be abnormal, or atypical, moles.