If you are pregnant or trying to become pregnant, avoid eating papaya or using a papaya product. Papaya is sometimes recommended for soothing indigestion, which is a common ailment during pregnancy. Although a fully ripe papaya is not considered dangerous, a papaya that is at all unripe contains a latex substance that triggers uterine contractions. ¹ Contractions of the uterus could lead to a miscarriage.

The papaya enzyme that helps soothe indigestion is called papain, or vegetable pepsin. Papain is found in the fruit's latex and leaves. ¹ Researchers have noted that unripe papaya latex acts like prostaglandin and oxytocin, which the body makes to start labor. ² Synthetic prostaglandin and oxytocin are commonly used to start or strengthen labor contractions.