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Genetic determinants of blood Rh factor

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By Kathe Gallagher, MSW

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Your blood's Rh factor is either positive (Rh+) or negative (Rh-). The Rh+ gene is more common than the Rh- gene, and is dominant.

  • If one of your two Rh genes is Rh+ and the other is Rh-, your blood type is Rh+.
  • It takes a pair of Rh- genes to make your blood type Rh-.

When an Rh- woman conceives with an Rh+ man, it is probable that their offspring will be Rh+.

  • If the father has two Rh+ genes, the fetus will inherit an Rh+ gene. That Rh+ gene, paired with the mother's Rh- gene, will result in an Rh+ fetal blood type.
  • If the father has one Rh+ and one Rh- gene, the fetus will inherit one of them, either:
    • An Rh+ gene, resulting in an Rh+ fetal blood type, or
    • An Rh- gene which, when paired with the mother's Rh- gene, results in an Rh- fetal blood type.

Credits

Author Kathe Gallagher, MSW
Editor Kathleen M. Ariss, MS
Editor Susan Van Houten, RN, BSN, MBA
Associate Editor Tracy Landauer
Primary Medical Reviewer Joy Melnikow, MD, MPH - Family Medicine
Specialist Medical Reviewer Gregory A L Davies, MD, FRCSC, FACOG - Maternal-Fetal Medicine
Last Updated November 2, 2007
Last Updated: 11/02/2007