Standard care for people with small lung tumors calls for surgical
removal of the affected lobe, but some people cannot have surgery because
of other medical conditions, such as heart disease or emphysema.
"Our goal has been to find a reasonable option for patients who don't
want or can't tolerate surgery," the study's lead author, Dr. Brian T.
Collins, a radiation oncologist at the Lombardi Comprehensive Cancer
Center at Georgetown University Hospital, said in a news release from the
university. "What we discovered is a very promising option that may be
relevant for other stage 1 patients as well. More follow-up with these
patients is planned to see how they progress five years after
treatment."
Stereotactic radiosurgery, despite its name, is not surgery but rather
a type of radiation therapy that focuses high-powered X-rays on abnormal
tissue only, sparing nearby healthy tissue.
The study included 24 people with early-stage lung cancer. Three years
after undergoing stereotactic radiosurgery, overall survival was 79
percent. Five deaths were attributed to progressive lung dysfunction. But
among those with better lung function, survival was 100 percent, the
researchers reported. The treatment was found to be well tolerated, with
most people reporting only mild fatigue.
"What we also learned from this study is that patients with poorer lung
functioning don't do nearly as well," Collins stated in the news release.
The overall survival in this group of patients was only 30 percent, the
researchers found.
"This information is important for the doctor and patient when making
treatment decisions. In treating someone with poor lung function, it would
seem prudent to modify the treatment dose in order to reduce further
damage to the lungs that stereotactic radiosurgery causes," Collins added.
The study was scheduled to be presented Nov. 3 at the American Society
of Chest Physicians annual meeting in San Diego. It was funded by the
CyberKnife Society, a nonprofit group supported by Accuray, which makes
CyberKnife systems. Collins has been a paid clinical consultant for
Accuray.
More information
The Radiological Society of North America has more about stereotactic radiosurgery.