Omega-3 fatty acids are found in marine or plant sources, such as fish oil and flaxseed oil. Preliminary studies suggest that people with bipolar disorder who take omega-3 fatty acids have a significantly longer period in which their mood is stable with no episodes of depression or mania (remission).¹

There are few, if any, negative side effects of taking omega-3 fatty acids. Loose stools were reported most often. Researchers think that omega-3 fatty acids may block signals in the central nervous system that trigger depression and mania. But more research needs to be conducted before there is sufficient evidence that omega-3 fatty acids improve the course of bipolar disorder.²