Post a CommentTorcetrapib: A Case of Profits vs. Patient Benefits
Posted By Simeon Margolis, M.D., Ph.D. - Thu, Dec 14, 2006, 11:26 pm PSTBecause of its dramatic ability to raise helpful HDL cholesterol, a new experimental drug called torcetrapib seemed likely to become a popular drug for the prevention of heart attacks and to earn huge profits…Read More
Promising HDL-boosting Drug Disappoints
Posted By Simeon Margolis, M.D., Ph.D. - Mon, Dec 11, 2006, 4:00 pm PSTMany studies have shown that the risk of heart disease is higher when high-density lipoprotein (HDL) cholesterol is low. The problem is that lifestyle measures and the available lipid-lowering medications…Read More
Gout Hurts Your Heart, Not Just Your Toe
Posted By Simeon Margolis, M.D., Ph.D. - Thu, Dec 07, 2006, 9:34 am PSTWe have all seen pictures of a middle-aged, overweight man with his foot swathed in bandages and grimacing in pain from an attack of gout in his big toe. Now it looks as if gout is responsible for more than…Read More
Chronic Kidney Disease Brings Higher Heart Attack Risk
Posted By Simeon Margolis, M.D., Ph.D. - Tue, Dec 05, 2006, 5:27 am PSTMany studies have shown that people with even mild chronic kidney disease (CKD) are at significantly higher risk for heart attacks and death. A National Kidney Foundation Task Force and other groups have…Read More
Wider Use of Heart Attack Screening Tests Recommended
Posted By Simeon Margolis, M.D., Ph.D. - Sun, Dec 03, 2006, 2:20 pm PSTAdvocating more widespread use of certain screening tests, new guidelines from the Screening for Heart Attack Prevention Education (SHAPE) Task Force are far more aggressive than those of the American Heart…Read More
More Benefits From Statins
Posted By Simeon Margolis, M.D., Ph.D. - Wed, Nov 29, 2006, 4:20 pm PSTStatins are widely used as the most effective medications we have to lower cholesterol. And recent research shows that statins also reduce the size of atherosclerotic plaques, a risk factor for heart disease.…Read More
Don't Mix Herbal Supplements and Coumadin
Posted By Simeon Margolis, M.D., Ph.D. - Mon, Nov 27, 2006, 12:22 am PSTWarfarin (Coumadin) is a medication commonly prescribed to prevent blood clots, especially in patients with atrial fibrillation. Patients who take warfarin must get periodic tests to check on the clotting…Read More
Strong Criticism of Metabolic Syndrome
Posted By Simeon Margolis, M.D., Ph.D. - Fri, Nov 24, 2006, 12:17 am PSTIn earlier entries, I've described the metabolic syndrome (a combination of high blood sugar and triglyceride levels, low HDL cholesterol, hypertension, and obesity) and its use to predict the likelihood of a…Read More
For Healthy Hearts, Pills Are Not Enough
Posted By Simeon Margolis, M.D., Ph.D. - Tue, Nov 21, 2006, 4:43 pm PSTA recent 16-year follow-up of nearly 43,000 men enrolled in the Heart Professionals Study found a substantial reduction in heart disease, both non-fatal and fatal, in the men who followed these five healthy…Read More
A New Drug for Chronic Angina
Posted By Simeon Margolis, M.D., Ph.D. - Tue, Nov 14, 2006, 11:56 am PSTIn January 2006, the FDA approved ranolazine (Ranexa) for the treatment of chronic angina, the most common form of angina (chest pain). Some form of angina affects close to 7 million Americans. Ranolazine is…Read More
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