By Simeon Margolis, M.D., Ph.D. Provided by: Johns Hopkins University

Your Healthy Heart

Lipoprotein (a): Another Heart Attack Risk Factor Posted Tue, Mar 27, 2007, 12:58 pm PDT

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  • 1. Posted by cgcurtin on Tue, Mar 27, 2007, 6:36 pm PDT

    How low do you try to lower the LDL? What is the optimal range if you have cardiovascular disease and are a man?

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  • 2. Posted by jimhealthy on Tue, Mar 27, 2007, 7:48 pm PDT

    How would agressive lowering of LDL, presumably with a statin, affect Lp(a)? I don't understand the logic of your protocol.

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  • 3. Posted by rlbruce1 on Sun, Apr 01, 2007, 3:35 am PDT

    So does lowering the LDL also help lower the Lp(a) level?? Your statement about apo(a)and its similar structure implies that the Lp(a)has clot busting properties and is a good thing so long as its not elevated?? What are the numbers in elevated Lp(a) that doctors should be looking for? Thank you.

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  • 4. Posted by sarara46 on Sun, Apr 01, 2007, 9:20 pm PDT

    Does vitamin k2 break up plaque?

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  • 5. Posted by deepa b on Sun, Apr 29, 2007, 3:15 pm PDT

    Pauling therapy may help to reduce Lipoprotein(a)levels. Pauling recommended Vitamin C and L-Lysine to lower Lipoprotein(a)levels.Later his colleague Rath, I think, added L-proline to this therapy so taking Vitamin C, lysin plus proline may help to lower Lipo(a)levels. One of the readers wanted to know what is the connection between agressively lowering LDL to Lipoprotein(a) levels. Probably Lipo(a)is an independent risk factor for CHD but Lipo(a)risk may get reduced if LDL is agressively reduced. Lipo(a)is genetic & normally does not respond to drugs or exercise. Neomycin(2g/day)& naicin(3g/day)may lower Lipo(a) levels but neomycin may cause damage to kidneys and/or nerves. Niacin should also be taken under supervision of a Doctor.

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  • 6. Posted by deepa b on Sun, Apr 29, 2007, 3:24 pm PDT

    One more thing,some one in comment section mentioned Lipoprotein(a)being good. NO,lipoprotein(a)is not good in any way as it is an independent risk factor for Coronary heart disease(CHD). Adults range should be less than 30.0 MG/DL. One last thing,Estrogen replacement therapy in postmenopausal women and high-dose niacin (at least 3-4 g/day) have been reported to lower Lp(a) levels but this should always be done under strict medical supervision.

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  • 7. Posted by cavanaughcathleen on Tue, Jun 05, 2007, 6:23 pm PDT

    I have high HDL's, low LDL's, and a very low ratio. I have a high Lipo-a. Does anyone know a cardiaologist in the Boston area interested in patients with Lipo-a issues?

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  • 8. Posted by 2bb on Wed, Jun 06, 2007, 8:24 am PDT

    good pages thanks

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  • 9. Posted by Seshadri K on Wed, Aug 29, 2007, 2:04 am PDT

    total chlorestrol 222mg% triglyceride163mg/% lipoprotein111mgs/dl could you advise on this

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  • 10. Posted by Seshadri K on Wed, Aug 29, 2007, 2:06 am PDT

    total chlorestrol 222mg% triglyceride163mg/% lipoprotein111mgs/dl could you advise on this

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  • 11. Posted by weedmessmom on Thu, Sep 06, 2007, 12:01 am PDT

    Have you taken time to read the Nobel-prize winning reasearch by Dr. Linus Pauling and Dr. Matthias Rath about theeir Vitamin C, proline, and lysine combination that not only can prevent lipoprotein(a) from "sticking" to lesions in weakened blood vessel walls, but it can also remove existing plaques. Readers should google search these topics, as well as the lifesaving benefits of magnesium, vitamin E(all 8 types), the B vitamins, and other essential nutrients that our dangerous processed "modern" foods strip from our nutrition. I could go on and on...the research is all there for even the average person to read by doing google searches. It's sad that the pharmaceutical companies have doctors so busy trying to keep up with their unending production of new (and dangerous) drugs that lay people like me have more time to read the research than doctors do. Dr. Pauling and Dr. Rath have found the cause (and cure) for heart disease (and also cancer) and the word is not getting out! I fear that making money is more important than saving lives. Legitimate research and treatments have been successfully discredited or ignored by being labeled "alternative medicine." It is time for our doctors to break free from the yoke of the drug companies and start reading and implementing livesaving nutritional and cellular health research on behalf of their patients. Read, read, read. ...if you really want to live by your hiipocratic oath and "DO no harm". Laurie M (Who recently beat cancer with "alternative medicne")

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  • 12. Posted by weedmessmom on Thu, Sep 06, 2007, 12:37 am PDT

    Everyone should read Dr. Matthias Rath's book Why Animals Don't Get Heart Attacks...But People Do. It is very short and to the point, great diagrams, easy to understand, and will save lives. I also highly recommend The High Blood Pressure Hoax by Dr. Sherry Rogers. You'll learn that high cholesterol is not even worth worrying about. Instead have your doctor test you for these critically important levels: lipoprotein(a), C-reactive Protein, RBC magnesium (not the worthless serum levels they usually do),H. Pylori, male or female hormone panel (which will be low if you have been put on cholesterol-lowering drugs),etc. Did you know that we NEED cholesterol for the sex hormones testosterone and estrogen, stress hormones like adrenaline, for bile acids so we can absorb our fat soluble vitamins E,D, E, K,plus lipoc acid, betacoartene, and the essential fatty acids like EPA and DHA, as well as coenzyme Q10? The cholesterol-lowering statin drugs cause a spiral of health problems such as heart disease, CANCERS, Alzheimers,etc. By turning off thea needed enzyme drugs like Lipitor turn off your body's natural production of co-enzyne Q10 that leads to depression, memory loss, tooth loss, and heart disease. How many people do you know who are depressed and have been prescribed antidepressants? Way too many. I suggest doing a google search on the benefits of Magnesium in heart disease. Get the word out....there are safer ways to reverse/cure heart disease, cancer, and diabetes than pharmaceutical drugs and dangerous surgery, but you have to search for the information because your doctors are too busy to do it for you. I am sure that heart surgeons and cardilolgists don't want the public to learn there are alternatives (prevention and cures) as their incomes would surely suffer. Hopefully many of them care about doing what is right more than making money. That is our only hope for improving health and saving lives in the US. Knowledge is power. So please read and search and save your selves and your loved ones. Laurie (a registered nurse)

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  • 13. Posted by asnicaam on Mon, Oct 15, 2007, 2:37 pm PDT

    Thank you so much for such a wealth of information. Thank you for all the time you all have spent gathering all of these studies. God bless you. Alida Schnell

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  • 14. Posted by Steven B on Fri, Nov 23, 2007, 1:40 pm PST

    You're basing your own treatment program vis-a-vis niacin on the basis of your experience with two patients? And then writing about it here at Yahoo where thousands of people may be impacted by your opinion? Shame on you doctor! There are real experts on this issue. For example, Dr. William Davis of http://heartscanblog.blogspot.com/. Dr. Davis has assisted his patients in actually REDUCING their plaque burden. Perhaps you could learn a few things from him before making statements about niacin that contradict the scientific literature?

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  • 15. Posted by chris5volley on Sat, Feb 23, 2008, 4:39 pm PST

    Good overview on subject of lipoprotein risk in cardiovascular disease.

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