By Simeon Margolis, M.D., Ph.D. Provided by: Johns Hopkins University

Behind the Headlines

Aspirin: Will It Prevent Heart Attack and Stroke? By Simeon Margolis, M.D., Ph.D. - Posted Wed, Nov 19, 2008, 3:42 pm PST

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  • 1. Posted by A Yahoo! Health User on Wed, Nov 19, 2008, 5:05 pm PST

    My fiancée (a Nurse Practitioner) has asked me to take an 81 mg Aspirin and Fish Oil daily. I had to take an anti-thyroid medication almost daily for over seven years and have "pill-fatigue." I am euthyroid now and question taking Aspirin when I am not in distress otherwise. Thanks for the article, I really should have asked my MD before starting the new regimen.

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  • 2. Posted by A Yahoo! Health User on Wed, Nov 19, 2008, 5:06 pm PST

    My fiancée (a Nurse Practitioner) has asked me to take an 81 mg Aspirin and Fish Oil daily. I had to take an anti-thyroid medication almost daily for over seven years and have "pill-fatigue." I am euthyroid now and question taking Aspirin when I am not in distress otherwise. Thanks for the article, I really should have asked my MD before starting the new regimen.

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  • 3. Posted by A Yahoo! Health User on Wed, Nov 19, 2008, 10:25 pm PST

    Informations usually beneficial as communication is, the knowledge acquired through the different situations will surely be helpfull to evaluate ones uncertainty of the benefit of on the counter medicine.

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  • 4. Posted by A Yahoo! Health User on Thu, Nov 20, 2008, 5:08 am PST

    My long years doubt has been cleared as i am a regular user of Asprin .thankyou.

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  • 5. Posted by A Yahoo! Health User on Thu, Nov 20, 2008, 7:11 am PST

    Seems like if you wait long enough the news will come out that a drug or practice has been reversed.Salt,aspirin use being two. It makes me wonder if aspirin was $5-$100 a pill if it wouldn't be made a wonder cure.

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  • 6. Posted by A Yahoo! Health User on Fri, Nov 21, 2008, 6:30 am PST

    A substantial number of people without any prior history or evidence of vascular disease of heart or brain suffers from first massive heart-attack or brain-stroke with death or severe permanent damange of heart and brain. so i think people with substantial risk and without contraindication should be prescribed aspirin. although I am 67 and has hypertension i donot take aspirin as my mother and elder brother died of haemorragic stroke. i would like to know wheather a family history of haemorragic stroke is an indication or contraindiction.

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  • 7. Posted by A Yahoo! Health User on Fri, Nov 21, 2008, 6:39 am PST

    I take one as secondary even though I have never had a heart attack. I had quadruple bypass at age 51. I found it when I was doing my nightly bicycle ride and I got a little short of breath at the beginning of the ride. I asked my friend, and doctor, and he had me come in, sent me to a cardiologist the next day who scheduled me for a heart cath, and then for open heart surgery the following day. But, back to the aspirin, if nothing else it is good for my arthritis.

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  • 8. Posted by A Yahoo! Health User on Fri, Nov 21, 2008, 9:39 pm PST

    If you wanted to discontinue your low dose aspirin, how would you go about doing it? I've heard that stopping aspirin suddenly might cause a stroke.

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  • 9. Posted by A Yahoo! Health User on Tue, Dec 16, 2008, 9:40 pm PST

    Interesting and useful information and needed to be publisized over and over again .As a pharmacologist teaching drugs for the last 22 years and loving every minute of it ;i agree totaly with you.FDA should aknowledge the results of clinical trials and be quick in updating their recomendation.Keep up the good work . Dr.Yacoub/Saudi arabia

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  • 10. Posted by A Yahoo! Health User on Tue, Dec 16, 2008, 9:49 pm PST

    Interesting and useful information and needed to be publisized over and over again .As a pharmacologist teaching drugs for the last 22 years and loving every minute of it ;i agree totaly with you.FDA should aknowledge the results of clinical trials and be quick in updating their recomendation.Keep up the good work . Dr.Yacoub

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  • 11. Posted by A Yahoo! Health User on Fri, Jan 23, 2009, 10:31 pm PST

    Almost on a daily basis, one may read about a new medication being developed or approved for the benefit of patients with a particular medical condition or disease state that they may have at the time. At times, these announcements may praise the innovation and novelty of such new drugs that are available to all in need of it, and rightfully so, in many situations. But it’s possible the one super drug is not new and really may be a super drug. In fact, it’s one of the oldest medications available, and that would be aspirin- the first non-steroidal anti-inflammatory drug (NSAID) initially for those patients experiencing pain. Noted as ASA by doctors typically, aspirin effects have been noted for thousands of years, as the active ingredient comes from the bark of a White Willow tree, and long ago, patients with pain or a fever would chew on this bark for relief. Yet due to the harshness of the natural chemical of this bark, Bayer decided to synthesize it to make it more tolerable for the user. Fast forward to over a hundred years ago and Bayer pharmaceuticals (pronounced ‘Beier’), which is the same company that brought us heroin (named so due to its perceived ‘heroic’ qualities as a believed non-addictive substitute for morphine addicts) and mustard gas, as well as methadone. The company originated in Germany, but presently has its U.S. headquarters in New York. Felix Hoffman, seeking to develop an agent for his father’s rheumatism, was involved in the development of what is known now as aspirin. And it was a difficult task to develop this drug, as it was toxic to the stomach due to the nature of the active ingredient again obtained from the bark of the white willow tree. Dr. Hoffman and others at Bayer developed a drug that proved to be tolerable to patients while keeping the active ingredient in tact through a method of delivery developed by Dr. Hoffman’s team at Bayer. After launching the medication, aspirin was priced at about 50 cents an ounce, as at the time it was only available in power form. Soon before 1920, aspirin developed the tablet form of the drug and was then available by prescription. Regardless, aspirin was responsible for one third of sales for Bayer during this time, due to its popularity due to the effects of this medication in need of relief. While all drugs have side effects, aspirin is one of very few drugs that offers suitable efficacy with perhaps mild side effects associated with the drug, comparatively speaking. Aspirin has been found to be beneficial for a wide variety of disease states. In fact, some of aspirin’s additional uses have been only recently discovered. This may be why the New York Times called aspirin a wonder drug in the 1960s, according to others. In the 1970s, the mechanism of aspirin was isolated, which is the blockage of prostaglandins. Prostaglandins are inside the human body and are a contributor for physiological inflammation. Aspirin has been associated with decreased risk of asthma and prostate cancer in the elderly. Also, aspirin has been linked with lowering the risk of breast cancer and colon cancer as well. Yet these conclusions are based on limited research with aspirin. Aspirin is a blood thinner, and has been associated with decreasing the risk of heart attacks and strokes in certain patient populations, as the drug prevents clots. However, aspirin has not been shown to prevent heart attacks in diabetic patients. The cardiovascular benefits of aspirin were first suggested in the 1940s, and the FDA suggested that it be the drug of choice for those who experienced a heart attack over a decade ago. Aspirin intake is also beneficial for those after coronary bypass procedure. In addition, aspirin has been shown to reduced blood pressure with those who have mild hypertension%2

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  • 12. Posted by A Yahoo! Health User on Thu, Feb 05, 2009, 9:32 am PST

    What are the side effects of aspirin regimen? What is considered mild hypertension?

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  • 13. Posted by A Yahoo! Health User on Fri, Feb 06, 2009, 6:05 pm PST

    There are many people who are taking Aspirin daily to prevent heart attacks, and very few actually are aware of the side effects. Thornhill Dentist http://www.bcdentalcare.ca

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  • 14. Posted by A Yahoo! Health User on Thu, Oct 29, 2009, 6:35 am PDT

    Yes there is this myth surrounding aspirin, how far it is true and effective nobody knows, but i believe regular exercise and a healthy lifestyle will help a great deal.

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