New storage instructions were just announced for Byetta (exenatide), an injectable medication for people with type 2 diabetes that can be used in combination with most oral diabetes medicines. You no longer need to refrigerate the pen containing your current dose of Byetta — however, do refrigerate any pens for future use.
So now you know about Byetta storage. But, believe it or not, many of my patients still tell me that they don't carry their insulin with them because they believe (mistakenly) it must be kept refrigerated.
Yes, your supply of insulin vials and pens will likely come refrigerated from the pharmacy, and please do store your future supply in the refrigerator. But you do not need to keep your current dose refrigerated.
Insulin can indeed lose its potency if it is not properly stored, however, so let's review some of the storage guidelines for this life-saving medication:
- Insulin pens and vials currently in use can be stored at room temperature. This is handy because injecting refrigerated insulin can be more painful or cause irritation at the injection site.
- Most vials of insulin can be stored at room temperature for up to 28 days.
- Insulin pens can be kept at room temperature anywhere from 10-28 days (depending on the type of insulin).
- Any opened or unopened vials or pens of insulin that have remained at room temperature for longer than 28 days should be thrown out.
- Insulin not in use should be refrigerated at a temperature between 36 degrees and 46 degrees Fahrenheit.
- If your insulin freezes, throw it out. Freezing destroys its potency.
- Always check the expiration date on your box or vial of insulin. Do not use it past that date.
- Always inspect your insulin prior to use. Some insulins should be clear, such as regular, aspart, lispro, glulisine, glargine, detemir insulins. If you see any discoloration or particles, don't use it. Some insulins, like NPH and mixed insulins, are normally cloudy, but even these should not be used if you can see floating particles or clumps in the vial.
Keep your medications at maximum strength by storing them properly. If you have any questions about storage, call your doctor or pharmacist.


