The following warning signs may be present in adults who have a high risk for suicide:

• Depression or other mental health condition, such as severe anxiety, bipolar disorder (manic-depressive illness), or schizophrenia
• Depression followed by sudden cheerfulness and contentment, which may mean the person has made a decision to finalize a suicide plan
• A previous suicide attempt
• Alcohol or substance abuse
• Preoccupation with death in conversations
• Giving away personal possessions

Factors that may increase the risk of suicide include having:

• A family member who has committed suicide.
• A family history of depression, bipolar disorder, or schizophrenia.
• A history of physical or sexual abuse.
• Diagnosis of a serious medical illness.
• Failing relationships.
• A divorce.
• A recent life change, such as a death of a spouse or other member of the family, marriage, break-up of a marriage, the birth of a child, a job loss, a job promotion or demotion, or legal problems.

FDA Advisories.. The U.S. Food and Drug Administration (FDA) has issued:

• An advisory on antidepressant medicines and the risk of suicide. The FDA does not recommend that people stop using these medicines, but to watch for warning signs of suicide in those using them. This is especially important at the beginning of treatment or when doses are changed.
• A warning about the antidepressants Paxil and Paxil CR and birth defects. Taking these medicines in the first 12 weeks of pregnancy may increase your chance of having a baby with a birth defect.