Familial Adenomatous Polyposis

Synonyms

• FAP
• Adenomatous polyposis of the colon (APC)
• Multiple Polyposis of the Colon
• Hereditary Polyposis Coli
• Familial Multiple Polyposis

Disorder Subdivisions

• Gardner Syndrome
• Turcot Syndrome
• familial adenomatous polyposis
• attenuated FAP

General Discussion

Familial adenomatous polyposis (FAP) is a rare inherited cancer predisposition syndrome characterized by hundreds to thousands of precancerous colorectal polyps (adenomatous polyps). If left untreated, affected individuals inevitably develop cancer of the colon and/or rectum. FAP is inherited in an autosomal dominant manner and caused by abnormalities (mutations) in the APC gene. Mutations in the APC gene cause a group of polyposis conditions that have overlapping features: familial adenomatous polyposis, Gardner syndrome, Turcot syndrome and attenuated FAP.
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Resources

March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: (914)428-7100
Fax: (914)997-4763
Tel: (888)663-4637
Email: Askus@marchofdimes.com
Internet: http://www.marchofdimes.com

Familial GI Cancer Registry
Mt. Sinai Hospital
600 University Avenue
Suite 1157
ON, M5G 1X5
Canada
Tel: 4165868334
Fax: 4165868644
Email: tberk@mtsinai.on.ca
Internet: http://www.mtsinai.on.ca/familialgicancer

Intestinal Multiple Polyposis and Colorectal Cancer Registry
P.O. Box 11
Conyngham, PA 18219
Tel: (717)788-3712
Fax: (717)788-4046
Email: user291524@aol.com

American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta, GA 30329
USA
Tel: 4043203333
Tel: 8002272345
Internet: http://www.cancer.org

Familial Polyposis Registry
Department of Colorectal Surgery
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195-5001
Tel: (216)444-6470

Hereditary Colorectal Cancer Registry
550 N. Broadway
Suite 108
Baltimore, MD 21205-2011
USA
Tel: 4109554041
Email: hccregistry@jhmi.edu
Internet: http://www.coloncancer.org

NIH/National Digestive Diseases Information Clearinghouse
2 Information Way
Bethesda, MD 20892-3570
Tel: (301)654-3810
Fax: (301)907-8906
Tel: (800)891-5389
Email: nddic@info.niddk.nih.gov
Internet: http://www.niddk.nih.gov

National Cancer Institute
6116 Executive Blvd, MSC 8322, Room 3036A
Bethesda, MD 20892-8322
USA
Tel: 3014353848
Tel: 8004226237
TDD: 8003328615
Internet: http://www.cancer.gov

Southeastern Hereditary Colorectal Cancer Registry
University Hospital
1350 Walton Way
Augusta, GA 30910-3599
USA
Tel: 7067748900
Fax: 7067748915
Email: cwheeler@uh.org

Delaware Cancer Registry
2055 Limestone Rd
Suite 213
Wilmington, DE 19808
Tel: (302)995-8605
Fax: (302)995-8250
Email: cmarker@state.de.us

Roswell Park Family Cancer Registry
Elm & Carlton Streets
Buffalo, NY 14263
Tel: (716)845-8400
Fax: (716)845-4556
Tel: (800)685-6825
Email: askrpci@roswellpark.org
Internet: http://www.roswellpark.org

Ferguson Hospital
71 Sheldon Boulevard
S.E.
Grand Rapids, MI 49503
Tel: (616)456-0202

Northwestern University Medical School
Department of Surgery
233 East Erie Street
Suite 100
Chicago, IL 60611
Tel: (312)943-5427

M. D. Anderson Cancer Center Hereditary Colorectal Cancer Registry
Department of Gastrointestinal Oncology
M.D. Anderson Cancer Center
Box 78, 1515 Holcombe Blvd.
Houston, TX 77030
Tel: (713)792-3245
Fax: (713)745-1163
Tel: (800)392-1611
Email: hcc-editor@mdacc.tmc.edu
Internet: http://www3.mdanderson.org/depts/hcc/registries.htm

OncoLink: The University of Pennsylvania Cancer Center Resource
3400 Spruce Street
2 Donner
Philadelphia, PA 19104-4283
USA
Tel: 2153495445
Fax: 2153495445
Email: editors@oncolink.upenn.edu
Internet: http://www.oncolink.upenn.edu

Strang-Cornell Hereditary Colon Cancer Program
428 East 72nd Street
New York, NY 10021
USA
Tel: 2127944900
Fax: 2127944958
Email: mbertagnolli@partners.org
Internet: http://www.strang.org

MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
USA
Tel: 9203365333
Fax: 9203390995
Tel: 8773365333
Email: mums@netnet.net
Internet: http://www.netnet.net/mums/

Friends of Cancer Research
2231 Crystal Drive
Suite 200
Arlington, VA 22202
Tel: (703)302-1503
Fax: (703)302-1568
Email: info@focr.org
Internet: http://www.focr.org

Cancer.Net
American Society of Clinical Oncology
2318 Mill Road
Suite 800
Alexandria, VA 22314
Tel: (571)483-1780
Fax: (571)366-9537
Tel: (888)651-3038
Email: contactus@cancer.net
Internet: http://www.cancer.net/patient

Wellness Community
919 18th Street N.W.
Suite 54
Washington, DC 20006
Tel: (202)659-9709
Fax: (202)659-9301
Tel: (888)793-9355
Email: help@thewellnesscommunity.org
Internet: http://www.thewellnesscommunity.org

Desmoid Tumor Research Foundation
P.O. Box 273
Suffern, NY 10901
Tel: (914)262-6595
Fax: (845)369-8302
Email: info@dtrf.org
Internet: http://www.dtrf.org

Lance Armstrong Foundation
PO Box 161550
Austin, TX 78716-1150
Tel: (512)236-8820
Fax: (512)236-8482
Tel: (866)235-7205
Internet: http://www.livestrong.org

CORE
3 St. Andrews Place
London, NW1 4LB
UK
Tel: 020 7486 0341
Fax: 020 7224 2012
Email: info@corecharity.org.uk
Internet: http://www.corecharity.org.uk

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  10/8/2008
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