Wolf Hirschhorn Syndrome

Synonyms

• WHS
• Wolf Syndrome
• Wolf-Hirschhorn Chromosome Region (WHCR)
• WHCR
• Chromosome 4, Partial Deletion 4p
• Partial Deletion of the Short Arm of Chromosome 4
• Chromosome 4, Partial Monosomy 4p
• 4p- Syndrome, Partial

Disorder Subdivisions

• None

General Discussion

Wolf-Hirschhorn syndrome is an extremely rare chromosomal disorder caused by a partial deletion (monosomy) of the short arm ("p") of chromosome 4. Major symptoms may include extremely wide-set eyes (ocular hypertelorism) with a broad or beaked nose, a small head (microcephaly), low-set malformed ears, mental and growth deficiency, heart (cardiac) defects, and seizures. Because the amount of genetic material deleted varies, the symptoms of this syndrome vary from case to case.

Resources

Chromosome Deletion Outreach, Inc.
P.O. Box 724
Boca Raton, FL 33429-0724
USA
Tel: 5613954252
Fax: 5613954252
Email: info@chromodisorder.org
Internet: http://www.chromodisorder.org

4P- Support Group
P.O. Box 1676
Gresham, OR 97030
United States
Tel: 5036617546
Email: fourthchromosome@aol.com
Internet: http://www.4p-supportgroup.org

Wolf-Hirschhorn Syndrome Support Group
1 Hawthorne Villas
Holmes Chapel
Crewe, CW4 7AR
United Kingdom
Tel: 01477 549465
Email: whs@webk.co.uk
Internet: http://www.whs.webk.co.uk/

World Health Organization (WHO) Regional Office for the Americas (AMRO)
Pan American Health Organization (PAHO)
525 23rd Street NW
Washington, DC 20037
Tel: (202)974-3000
Fax: (202)974-3663
Email: postmaster@paho.org
Internet: http://www.who.ch/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated: 4/4/2005
Copyright 1989, 1992, 1995, 1996, 1998, 2005 National Organization for Rare Disorders, Inc.