Fibrin glue is a pasty substance that is applied directly on a wound (topically) and is most often used after dental procedures to treat people with bleeding problems. Fibrin glue contains clotting factors to help a wound stop bleeding. It is used for people who lack or have a shortage of clotting factor VIII.

Thrombin powder is a dry powder that can be applied directly to the top of a wound to stop minor bleeding.

People who have a blood-clotting disorder such as von Willebrand's disease or hemophilia may be treated with fibrin glue or thrombin powder to help control bleeding.